Multiple roles of CD90 in cancer

A Kumar, A Bhanja, J Bhattacharyya, BG Jaganathan - Tumor Biology, 2016 - Springer
Abstract THY1 (CD90) is a 25–37-kDa heavily N-glycosylated, glycophosphatidylinositol
(GPI) anchored cell surface protein. It is usually expressed on thymocytes, mesenchymal …

The impact of Epstein-Barr virus infection on epigenetic regulation of host cell gene expression in epithelial and lymphocytic malignancies

MML Leong, ML Lung - Frontiers in Oncology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) infection is associated with a variety of malignancies including
Burkitt's lymphoma (BL), Hodgkin's disease, T cell lymphoma, nasopharyngeal carcinoma …

A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells

DA Moraes, TT Sibov, LF Pavon, PQ Alvim… - Stem cell research & …, 2016 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) are multipotent progenitor cells
used in several cell therapies. MSCs are characterized by the expression of CD73, CD90 …

A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

KH Tang, YD Dai, M Tong, YP Chan, PS Kwan… - Cancer …, 2013 - aacrjournals.org
Abstract Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely
as a specific subpopulation of cells needed for cancer initiation and progression. TICs have …

Extracellular Protease ADAMTS9 Suppresses Esophageal and Nasopharyngeal Carcinoma Tumor Formation by Inhibiting Angiogenesis

PHY Lo, HL Lung, AKL Cheung, SS Apte… - Cancer …, 2010 - aacrjournals.org
ADAMTS metalloprotease family member ADAMTS9 maps to 3p14. 2 and shows significant
associations with the aerodigestive tract cancers esophageal squamous cell carcinoma …

Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma

EWL Law, AKL Cheung, VI Kashuba, TV Pavlova… - Oncogene, 2012 - nature.com
Abstract Fibulin-2 (FBLN2) has been identified as a candidate tumor-suppressor gene in
nasopharyngeal carcinoma (NPC). Originally identified through a chromosome 3 NotI …

Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression

C Penas, Y Arroyo-Berdugo, A Apraiz, J Rasero… - Scientific Reports, 2023 - nature.com
Originally considered to act as a transcriptional co-factor, Pirin has recently been reported to
play a role in tumorigenesis and the malignant progression of many tumors. Here, we have …

The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma

ML Lung, AKL Cheung, JMY Ko… - Chinese journal of …, 2014 - pmc.ncbi.nlm.nih.gov
The interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes
to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic …

The landscape of candidate driver genes differs between male and female breast cancer

I Johansson, M Ringnér, I Hedenfalk - PloS one, 2013 - journals.plos.org
The rapidly growing collection of diverse genome-scale data from multiple tumor types
sheds light on various aspects of the underlying tumor biology. With the objective to identify …

Nuclear localization of DNAJB6 is associated with survival of patients with esophageal cancer and reduces AKT signaling and proliferation of cancer cells

VZ Yu, VCL Wong, W Dai, JMY Ko, AKY Lam, KW Chan… - Gastroenterology, 2015 - Elsevier
Background & Aims The DnaJ (Hsp40) homolog, subfamily B, member 6 (DNAJB6) is part of
a family of proteins that regulates chaperone activities. One of its isoforms, DNAJB6a …