Metastasis
Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …
Chromosomal instability as a driver of cancer progression
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
Using a pan-cancer atlas to investigate tumour associated macrophages as regulators of immunotherapy response
The paradigm for macrophage characterization has evolved from the simple M1/M2
dichotomy to a more complex model that encompasses the broad spectrum of macrophage …
dichotomy to a more complex model that encompasses the broad spectrum of macrophage …
Advances in single-cell RNA sequencing and its applications in cancer research
D Huang, N Ma, X Li, Y Gou, Y Duan, B Liu… - Journal of hematology & …, 2023 - Springer
Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
[HTML][HTML] Spatially resolved transcriptomics: a comprehensive review of their technological advances, applications, and challenges
The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …
technology, from the invention of the microscope 350 years ago to the recent emergence of …
A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma
Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has
a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells …
a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells …
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens
Single-cell genomics enables dissection of tumor heterogeneity and molecular
underpinnings of drug response at an unprecedented resolution,,,,,,,,,–. However, broad …
underpinnings of drug response at an unprecedented resolution,,,,,,,,,–. However, broad …
Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain
Brain metastasis, a serious complication of cancer, hinges on the initial survival,
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
Late-stage metastatic melanoma emerges through a diversity of evolutionary pathways
Understanding the evolutionary pathways to metastasis and resistance to immune-
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Brain metastases represent an important clinical problem for patients with small-cell lung
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …