Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

Tissue-like structures from human pluripotent stem cells containing multiple cell types are
transforming our ability to model and understand human development and disease. Here we …

Tissue injury can drive secondary organ injury; however, mechanisms and mediators are not
well understood. To identify interorgan cross-talk mediators, we used acute kidney injury …

We advance an account that grounds cognition, specifically decision-making, in an activity
all organisms as autonomous systems must perform to keep themselves viable—controlling …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …

Based on a deep generative model of variational graph autoencoder (VGAE), we develop a
new method, DeepLinc (deep learning framework for Landscapes of Interacting Cells), for …

The evolution of multicellular life has played a pivotal role in sha** biological diversity.
However, we know surprisingly little about the natural environmental conditions that favour …

Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain
bodily functions such as glucose metabolism. In particular, feedback loops focus on the …

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many
biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task …