Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Ovarian cancer is the eighth-most common cause of death among women worldwide. In the
absence of distinctive symptoms in the early stages, the majority of women are diagnosed in …

The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …

Signals mediated by the chemokine CXCL12 and its receptor CXCR4 are involved in the
progression of ovarian cancer through enhancement of tumor angiogenesis and …

Cancer stem cells are rare chemotherapy resistant cells within a tumor which can serve to
populate the bulk of a tumor with more differentiated daughter cells and potentially …

Abstract High Grade Serous Ovarian cancer (HGSOC) is a major unmet need in oncology,
due to its precocious dissemination and the lack of meaningful human models for the …

Objectives The purpose of this study was to determine the level of heterogeneity in high
grade serous ovarian cancer (HGSOC) by analyzing RNA expression in single epithelial …

Epithelial ovarian cancer is the deadliest gynecologic cancer, due in large part to recurrent
tumors. Recurrences tend to have metastasized, mainly in the peritoneal cavity and …

Ovarian cancer remains the leading cause of gynecological cancer-related mortality despite
the advances in surgical techniques and chemotherapy drugs over the past three decades …

Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis
and tumor recurrence, therapeutic targeting of CSCs holds promise to address these clinical …