Toxoplasma gondii is an obligate intracellular protozoan parasite which is a significant
human and veterinary pathogen. Other members of the phylum Apicomplexa are also …

While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed
hydrolysis of the nucleosidic bond, their C-analogues are much more stable. Several C …

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better …

The field of isotope effects has expanded exponentially in the last decade, and researchers
are finding isotopes increasingly useful in their studies. Bringing literature on the subject up …

Identification of novel targets for the development of more effective antimalarial drugs and
vaccines is a primary goal of the Plasmodium genome project. However, deciding which …

Enzymes achieve their transition states by dynamic conformational searches on the
femtosecond to picosecond time scale. Mimics of reactants at enzymatic transition states …

Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and
vector control strategies have been applied for more than a century but have not been …

Genome‐scale metabolic reconstructions can serve as important tools for hypothesis
generation and high‐throughput data integration. Here, we present a metabolic network …

Synthesis de novo, acquisition by salvage and interconversion of purines and pyrimidines
represent the fundamental requirements for their eventual assembly into nucleic acids as …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …