Frailty measurement in research and clinical practice: a review

E Dent, P Kowal, EO Hoogendijk - European journal of internal medicine, 2016 - Elsevier
One of the leading causes of morbidity and premature mortality in older people is frailty.
Frailty occurs when multiple physiological systems decline, to the extent that an individual's …

Frailty in relation to the accumulation of deficits

K Rockwood, A Mitnitski - The Journals of Gerontology Series A …, 2007 - academic.oup.com
This review article summarizes how frailty can be considered in relation to deficit
accumulation. Recalling that frailty is an age-associated, nonspecific vulnerability, we …

Sex differences in frailty: a systematic review and meta-analysis

EH Gordon, NM Peel, M Samanta, O Theou… - Experimental …, 2017 - Elsevier
Background It is a well-described clinical phenomenon that females live longer than males,
yet tend to experience greater levels of co-morbidity and disability. Females can therefore be …

A comparison of two approaches to measuring frailty in elderly people

K Rockwood, M Andrew… - The Journals of …, 2007 - academic.oup.com
Background. Many definitions of frailty exist, but few have been directly compared. We
compared the relationship between a definition of frailty based on a specific phenotype with …

Measures of frailty in population-based studies: an overview

K Bouillon, M Kivimaki, M Hamer, S Sabia, EI Fransson… - BMC geriatrics, 2013 - Springer
Background Although research productivity in the field of frailty has risen exponentially in
recent years, there remains a lack of consensus regarding the measurement of this …

Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey

K Rockwood, X Song, A Mitnitski - Cmaj, 2011 - Can Med Assoc
Background The prevalence of frailty increases with age in older adults, but frailty is largely
unreported for younger adults, where its associated risk is less clear. Furthermore, less is …

Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study

AM Kulminski, SV Ukraintseva… - Journal of the …, 2008 - Wiley Online Library
OBJECTIVES: To compare how well frailty measures based on a phenotypic frailty approach
proposed in the Cardiovascular Health Study (CHS) and a cumulative deficits approach …

Social vulnerability, frailty and mortality in elderly people

MK Andrew, AB Mitnitski, K Rockwood - PloS one, 2008 - journals.plos.org
Background Social vulnerability is related to the health of elderly people, but its
measurement and relationship to frailty are controversial. The aims of the present study were …

[PDF][PDF] Validation of an index to estimate the prevalence of frailty among community-dwelling seniors

M Hoover, M Rotermann, C Sanmartin, J Bernier - Health Rep, 2013 - saigaiin.sakura.ne.jp
Background This study validates cut-points for a frailty index (FI) to identify seniors at risk of
a hospital-related event and estimates the number of frail seniors living in the community …

Disability and co-morbidity in relation to frailty: how much do they overlap?

O Theou, MRH Rockwood, A Mitnitski… - Archives of gerontology …, 2012 - Elsevier
The purpose of this study was to examine the association of disability and co-morbidity with
frailty in older adults. 2305 participants aged 65+ from the second wave of the Canadian …