Functions of muscarinic receptor subtypes in gastrointestinal smooth muscle: A review of studies with receptor-knockout mice

Y Tanahashi, S Komori, H Matsuyama… - International Journal of …, 2021 - mdpi.com
Parasympathetic signalling via muscarinic acetylcholine receptors (mAChRs) regulates
gastrointestinal smooth muscle function. In most instances, the mAChR population in smooth …

Muscarinic acetylcholine receptor subtypes in smooth muscle

RM Eglen, H Reddy, N Watson, RAJ Challiss - Trends in pharmacological …, 1994 - cell.com
Mttsmrittic~ re~~/~~~ ru~ jtte M2 a& M3 receptor stt~~~~ pt~ s RYE~~ e~~ resse~ itt nmtty
types of sfttoofit tttttsfle ittcltrdiitg gnstyoititesW7l sttrootlf trttrsc~ e, ttrittnry blndder attd mtscthr …

Muscarinic receptor subtypes of the bladder and gastrointestinal tract

T Uchiyama, R Chess-Williams - Journal of smooth muscle research, 2004 - jstage.jst.go.jp
The parasympathetic nervous system is responsible for maintaining normal intestinal and
bladder function, contracting the smooth muscle by releasing the neurotransmitters …

Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle

FJ Ehlert - Life sciences, 2003 - Elsevier
Both M2 and M3 muscarinic receptors are expressed in smooth muscle and influence
contraction through distinct signaling pathways. M3 receptors interact with Gq to trigger …

Cholinergic neurotransmission and muscarinic receptors in the enteric nervous system

AM Harrington, JM Hutson, BR Southwell - Progress in histochemistry and …, 2010 - Elsevier
There is a rich knowledge of the enteric nervous system (ENS), especially the
neurochemical and neurophysiological properties of enteric neurons and how they …

Muscarinic receptor subtypes controlling the cationic current in guinea‐pig ileal smooth muscle

AV Zholos, TB Bolton - British journal of pharmacology, 1997 - Wiley Online Library
1 The effects of muscarinic antagonists on cationic current evoked by activating muscarinic
receptors with the stable agonist carbachol were studied by use of patch‐clamp recording …

Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide

EA Thomas, MJ Carson, MJ Neal… - Proceedings of the …, 1997 - National Acad Sciences
The effects of oleamide, an amidated lipid isolated from the cerebrospinal fluid of sleep-
deprived cats, on serotonin receptor-mediated responses were investigated in cultured …

Subtypes of the muscarinic receptor in smooth muscle

FJ Ehlert, RS Ostrom, GW Sawyer - Life sciences, 1997 - Elsevier
Muscarinic receptors are expressed in smooth muscle throughout the body. In most
instances, the muscarinic receptor population in smooth muscle is composed of mainly the …

M2 and M3 muscarinic receptor‐mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice

T Unno, H Matsuyama, T Sakamoto… - British journal of …, 2005 - Wiley Online Library
Isometric contractile responses to carbachol were studied in ileal longitudinal smooth
muscle strips from wild‐type mice and mice genetically lacking M2 or M3 muscarinic …

M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.

LB Fernandes, AD Fryer… - The Journal of …, 1992 - jpet.aspetjournals.org
Classification of muscarinic receptors in the central airways has revealed the coexistence of
M2 and M3 muscarinic receptors in this tissue, with the M2 subtype being predominant …