Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

Multiple myeloma remains an incurable disease with the usual disease course requiring
induction therapy, autologous stem cell transplantation for eligible patients, and long-term …

Biological nanoparticles, such as exosomes, offer an approach to drug delivery because of
their innate ability to transport biomolecules. Exosomes are derived from cells and an …

Aims Apart from cardiotoxicity, the chemotherapeutic doxorubicin (DOX) induces vascular
toxicity, represented by arterial stiffness and endothelial dysfunction. Both parameters are of …

DNA topoisomerase II (Top2) is essential for all eukaryotic cells in the regulation of DNA
topology through the generation of temporary double-strand breaks. Cancer cells acquire …

Background: Cisplatin is employed in hyperthermic intraperitoneal chemotherapy (HIPEC)
after cytoreductive surgery (CRS) for peritoneal surface malignancies (PSMs). The main …

Doxorubicin (DOX) is one of the most widely used anticancer agents. DOX is known for
inducing cardiotoxicity, resulting in the long-term development of heart failure. Intravascular …

Simple Summary Understanding of the interactions of chemotherapeutic agents with cancer
cells in the presence of extracellular matrix (ECM) is necessary for improving drug delivery …

The use of doxorubicin (Dox) in cancer patients carries the risk of cardiotoxicity via an
increase in oxidative stress, mitochondrial dysfunction, and disturbed endoplasmic reticulum …

The unmet need to develop novel approaches for cancer diagnosis and treatment has led to
the evolution of theranostic agents, which usually include, in addition to the anticancer drug …