Targeting inflammation to treat diabetic kidney disease: the road to 2030

S Rayego-Mateos, RR Rodrigues-Diez… - Kidney international, 2023 - Elsevier
Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

[HTML][HTML] RONS and oxidative stress: an overview of basic concepts

AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Endothelial cell dysfunction and increased cardiovascular risk in patients with chronic kidney disease

CC Baaten, S Vondenhoff, H Noels - Circulation research, 2023 - ahajournals.org
The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and
regulating vascular integrity. In patients with chronic kidney disease, protective endothelial …

Diabetes and renal complications: an overview on pathophysiology, biomarkers and therapeutic interventions

R Jha, S Lopez-Trevino, HR Kankanamalage, JC Jha - Biomedicines, 2024 - mdpi.com
Diabetic kidney disease (DKD) is a major microvascular complication of both type 1 and type
2 diabetes. DKD is characterised by injury to both glomerular and tubular compartments …

Causal effects of systemic inflammatory regulators on chronic kidney diseases and renal function: a bidirectional Mendelian randomization study

H Li, M Li, C Liu, P He, A Dong, S Dong… - Frontiers in …, 2023 - frontiersin.org
Background While targeted systemic inflammatory modulators show promise in preventing
chronic kidney disease (CKD) progression, the causal link between specific inflammatory …

Ginkgo biloba and long COVID: in vivo and in vitro models for the evaluation of nanotherapeutic efficacy

T Akanchise, A Angelova - Pharmaceutics, 2023 - mdpi.com
Coronavirus infections are neuroinvasive and can provoke injury to the central nervous
system (CNS) and long-term illness consequences. They may be associated with …

Cardiovascular consequences of uremic metabolites: an overview of the involved signaling pathways

A Curaj, R Vanholder, J Loscalzo, K Quach… - Circulation …, 2024 - ahajournals.org
The crosstalk of the heart with distant organs such as the lung, liver, gut, and kidney has
been intensively approached lately. The kidney is involved in (1) the production of systemic …

Exploring the role of phenolic compounds in chronic kidney disease: a systematic review

F Baptista, J Paié-Ribeiro, M Almeida, AN Barros - Molecules, 2024 - mdpi.com
Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in
six adults over 25. This review explores the potential of phenolic compounds in managing …

[HTML][HTML] Therapeutic application of traditional Chinese medicine in kidney disease: Sirtuins as potential targets

Q **, T Liu, F Ma, L Yang, H Mao, Y Wang, P Li… - Biomedicine & …, 2023 - Elsevier
Sirtuins are a family of NAD+ III-dependent histone deacetylases that consists of seven
family members, Sirt1-Sirt7, which regulate various signalling pathways and are involved in …

The development of dyslipidemia in chronic kidney disease and associated cardiovascular damage, and the protective effects of curcuminoids

ZA Ceja-Galicia, AK Aranda-Rivera, I Amador-Martínez… - Foods, 2023 - mdpi.com
Chronic kidney disease (CKD) is a health problem that is constantly growing. This disease
presents a diverse symptomatology that implies complex therapeutic management. One of …