Allergen immunotherapy: past, present and future

SR Durham, MH Shamji - Nature Reviews Immunology, 2023 - nature.com
Allergen immunotherapy is a form of therapeutic vaccination for established IgE-mediated
hypersensitivity to common allergen sources such as pollens, house dust mites and the …

The role of allergen‐specific IgE, IgG and IgA in allergic disease

MH Shamji, R Valenta, T Jardetzky, V Verhasselt… - Allergy, 2021 - Wiley Online Library
Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease
affecting more than 30% of the population. Exposure to even minute quantities of allergens …

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper

M Jutel, I Agache, M Zemelka‐Wiacek, M Akdis… - Allergy, 2023 - Wiley Online Library
The exponential growth of precision diagnostic tools, including omic technologies, molecular
diagnostics, sophisticated genetic and epigenetic editing, imaging and nano‐technologies …

Mechanisms of allergen immunotherapy in allergic rhinitis

G Drazdauskaitė, JA Layhadi, MH Shamji - Current allergy and asthma …, 2021 - Springer
Abstract Purpose of Review Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin
(Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of …

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

O Palomares, M Akdis, M Martín‐Fontecha… - Immunological …, 2017 - Wiley Online Library
Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

[PDF][PDF] Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis

L Cheng, J Chen, Q Fu, S He, H Li… - Allergy, asthma & …, 2018 - synapse.koreamed.org
Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities
worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has …

Mechanisms of allergen-specific immunotherapy and allergen tolerance

UC Kucuksezer, C Ozdemir, L Cevhertas… - Allergology …, 2020 - jstage.jst.go.jp
abstract Allergen-specific immunotherapy (AIT) is the mainstay treatment for the cure of
allergic disorders, with depicted efficacy and safety by several trials and meta-analysis. AIT …

Allergy: Mechanistic insights into new methods of prevention and therapy

CA Akdis, M Akdis, SD Boyd, V Sampath… - Science Translational …, 2023 - science.org
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here,
we review the etiology and pathophysiology of allergic diseases, including the role of the …

Induction of interleukin-10 producing dendritic cells as a tool to suppress allergen-specific T helper 2 responses

S Schülke - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and
polarization of primary, antigen-specific immune responses. Depending on their …

Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens

M Akdis, CA Akdis - Journal of Allergy and Clinical Immunology, 2014 - Elsevier
Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a
desensitizing therapy for IgE-mediated allergic diseases and represents a potentially …