Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …

Autoinflammatory diseases are conditions in which pathogenic inflammation arises primarily
through antigen-independent hyperactivation of immune pathways. First recognized just …

Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

Neutrophils are important effector cells in the host defense against invading
microorganisms. One of the mechanisms they use to eliminate pathogens is the release of …

A growing number of monogenic immune-mediated diseases have been related to genes
involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate …

Autoinflammation as a distinct disease category was first reported in 1999 as a group of
monogenic disorders characterized by recurrent episodes of systemic and organ-specific …

The actin cytoskeleton is composed of dynamic filament networks that build adaptable local
architectures to sustain nearly all cellular activities in response to a myriad of stimuli …

CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin
network to drive the polarized secretion of lytic granules, initiating target cell death during …

Systemic autoinflammatory diseases (SAIDs) are defined as disorders of innate immunity.
They were initially defined in opposition to autoimmune diseases due to the lack of …

The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …