Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

Osteosarcoma is one of the most common types of bone cancers among paediatric patients.
Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of …

Triptolide, a traditional Chinese medicine, obtained from Tripterygium wilfordii Hook F, has
anti‐inflammatory, antiproliferative, and proapoptotic properties. We investigated the …

Background Osteosarcoma (OS) mainly occurs in children and adolescents, and has a high
propensity for lung metastasis. Little is known about the role of SDF-1/CXCR4 axis in OS …

Nature is an attractive source of therapeutic and preventive compounds, and with such
chemical diversity found in millions of species of plants, over 60% of currently used …

The present study aimed to investigate the effect of triptolide (TL) on ulcerative colitis (UC)
and explore the potential association between the therapeutic effects of TL and IL‑1β …

In order to evaluate the anticancer effect of 10-hydroxycamptothecin (HCPT) in terms of
inducing the apoptosis of human osteosarcoma cells, its apoptosis-inducing molecular …

Glioblastoma multiforme (GBM) is a highly malignant devastating brain tumor in adults.
Benzyl isothiocyanate (BITC) is one of the isothiocyanates that have been shown to induce …

Chronic inflammation often delays fracture healing or leads to bone nonunion. Effectively
suppressing pathological inflammation is crucial for fracture healing or bone remodeling …

Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment
alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor …