Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and
other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on …

Sphingolipid synthesis involves a highly conserved biosynthetic pathway that produces
fundamental precursors of complex sphingolipids. The final reaction involves the insertion of …

ABSTRACT ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is
currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and …

Dihydroceramides (DhCers) are a type of sphingolipids that for a long time were regarded
as biologically inactive. They are metabolic intermediates of the de novo sphingolipid …

Ceramides are composed of a sphingosine and a single fatty acid connected by an amide
linkage. As one of the major classes of biologically active lipids, ceramides and their …

Abstract Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide,
and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation …

Sphingolipid research has surged in the past two decades and has produced a wide variety
of evidence supporting the role of this class of molecules in mediating cellular growth …

Atherosclerosis—a systemic inflammatory disease—is the number one cause of mortality
and morbidity worldwide. As such, the prevention of disease progression is of global interest …

Pooled CRISPR screens have been widely applied to mammalian and other organisms to
elucidate the interplay between genes and phenotypes of interest. The most popular method …

Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not
contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph) …