Spatial and temporal control of chemical processes

S Aubert, M Bezagu, AC Spivey… - Nature Reviews …, 2019 - nature.com
Controlling the where and when of a chemical reaction, rather than just the if, can be an
essential component in the successful development of applications. There are a large …

Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies

O Couture, J Foley, NF Kassell, B Larrat… - Translational Cancer …, 2014 - tcr.amegroups.org
Therapeutic ultrasound has been used to thermally ablate solid tumors since the 90s, and a
variety of cancers are presently being treated clinically, taking advantage of ultrasound-or …

Step-emulsification in a microfluidic device

Z Li, AM Leshansky, LM Pismen, P Tabeling - Lab on a Chip, 2015 - pubs.rsc.org
We present a comprehensive study of the step-emulsification process for high-throughput
production of colloidal monodisperse droplets. The 'microfluidic step emulsifier'combines a …

Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies

A Mangraviti, D Gullotti, B Tyler, H Brem - Journal of Controlled Release, 2016 - Elsevier
Despite recent technological advancements and promising preclinical experiments, brain
tumor patients are still met with limited treatment options. Some of the barriers to clinical …

Bioorthogonal drug release from nanometric micelles in living cells

L Madegard, M Girard, BR Yaw, K Porte… - … A European Journal, 2023 - Wiley Online Library
We explored a bioorthogonal approach to release drugs from stimuli‐responsive micelles
inside tumor cells. The concept relies on sydnonimine‐based micelles that undergo …

Photoactivated in situ generation of near infrared cyanines for spatiotemporally controlled fluorescence imaging in living cells

G Song, H Heng, J Wang, R Liu, Y Huang… - Angewandte …, 2021 - Wiley Online Library
Abstract Photoactivated trimerization of 2, 3, 3‐trimethyl‐3H‐indole derivatives created near
infrared fluorophore Cy5. The synthetic method is air‐tolerant, photosensitizer free, metal …

Sequential release of nanoparticle payloads from ultrasonically burstable capsules

S Kennedy, J Hu, C Kearney, H Skaat, L Gu, M Gentili… - Biomaterials, 2016 - Elsevier
In many biomedical contexts ranging from chemotherapy to tissue engineering, it is
beneficial to sequentially present bioactive payloads. Explicit control over the timing and …

Spatially-directed cell migration in acoustically-responsive scaffolds through the controlled delivery of basic fibroblast growth factor

X Lu, H **, C Quesada, EC Farrell, L Huang… - Acta biomaterialia, 2020 - Elsevier
Hydrogels are commonly used in regenerative medicine for the delivery of growth factors
(GFs). The spatial and temporal presentations of GFs are critical for directing regenerative …

Patterning of Protein-Sequestered Liquid-Crystal Droplets Using Acoustic Wave Trap**

PM Naveenkumar, H Maheshwari, V Gundabala… - Langmuir, 2023 - ACS Publications
Development of spatially organized structures and understanding their role in controlling
kinetics of multistep chemical reactions are essential for the successful design of efficient …

Magnetoresponsive virus‐mimetic nanocapsules with dual heat‐triggered sequential‐infected multiple drug‐delivery approach for combinatorial tumor therapy

JH Fang, YT Lee, WH Chiang, SH Hu - Small, 2015 - Wiley Online Library
Stimuli‐responsive drug‐delivery systems constitute an appealing approach to direct and
restrict drug release spatiotemporally at the specific site of interest. However, it is difficult for …