The molecular basis of retinal ganglion cell death in glaucoma
M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …
results in visual field loss and irreversible blindness. A crucial element in the …
A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma
CF Burgoyne - Experimental eye research, 2011 - Elsevier
This article is dedicated to Rosario Hernandez for her warm support of my own work and her
genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario …
genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario …
Factors influencing optic nerve head biomechanics
purpose. The biomechanical environment within the optic nerve head (ONH) may play a role
in retinal ganglion cell loss in glaucomatous optic neuropathy. This was a systematic …
in retinal ganglion cell loss in glaucomatous optic neuropathy. This was a systematic …
Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
Biomechanics of the optic nerve head
Biomechanical factors acting at the level of the lamina cribrosa (LC) are postulated to play a
role in retinal ganglion cell dysfunction and loss in glaucoma. In support of this postulate, we …
role in retinal ganglion cell dysfunction and loss in glaucoma. In support of this postulate, we …
Aging and ocular tissue stiffness in glaucoma
Glaucoma is a progressive and chronic neurodegenerative disorder characterized by
damage to the inner layers of the retina and deformation of the optic nerve head. The …
damage to the inner layers of the retina and deformation of the optic nerve head. The …
Discovery and clinical translation of novel glaucoma biomarkers
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …
[HTML][HTML] Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations
Purpose.: To characterize scleral biomechanics in both eyes of eight monkeys in which
chronic intraocular pressure (IOP) elevation was induced in one eye. Methods.: Each …
chronic intraocular pressure (IOP) elevation was induced in one eye. Methods.: Each …
Mechanical environment of the optic nerve head in glaucoma
JC Downs, MD Roberts… - Optometry and Vision …, 2008 - journals.lww.com
The optic nerve head (ONH) is of particular interest from a biomechanical perspective
because it is a weak spot within an otherwise strong corneo-scleral envelope. The lamina …
because it is a weak spot within an otherwise strong corneo-scleral envelope. The lamina …
Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
Purpose.: To investigate whether longitudinal changes deep within the optic nerve head
(ONH) are detectable by spectral domain optical coherence tomography (SDOCT) in …
(ONH) are detectable by spectral domain optical coherence tomography (SDOCT) in …