Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …

Industrial strain development requires system-wide engineering and optimization of cellular
metabolism while considering industrially relevant fermentation and recovery processes. It …

We present here a broad overview of the field of metabolic engineering, describing in the
first section the key fundamental principles that define and distinguish it, as well as the …

Natural products are among the most important sources of lead molecules for drug
discovery. With the development of affordable whole-genome sequencing technologies and …

Genome-scale metabolic models bridge the gap between genome-derived biochemical
information and metabolic phenotypes in a principled manner, providing a solid …

Genome-scale metabolic network reconstructions in microorganisms have been formulated
and studied for about 8 years. The constraint-based approach has shown great promise in …

Integrated approaches utilizing in silico analyses will be necessary to successfully advance
the field of metabolic engineering. Here, we present an integrated approach through a …

Genome-scale metabolic models (GEMs) are valuable in describing an organism's entire
metabolism using genomic information and have made huge impact on systems biology and …

Although the genomes of many microbial pathogens have been studied to help identify
effective drug targets and novel drugs, such efforts have not yet reached full fruition. In this …