Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

RJ Mead, N Shan, HJ Reiser, F Marshall… - Nature Reviews Drug …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis

SA Goutman, O Hardiman, A Al-Chalabi… - The Lancet …, 2022 - thelancet.com
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

Amyotrophic lateral sclerosis

MA Van Es, O Hardiman, A Chio, A Al-Chalabi… - The Lancet, 2017 - thelancet.com
Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Amyotrophic lateral sclerosis

RH Brown, A Al-Chalabi - New England Journal of Medicine, 2017 - Mass Medical Soc
Amyotrophic Lateral Sclerosis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Amyotrophic lateral sclerosis: translating genetic discoveries into therapies

F Akçimen, ER Lopez, JE Landers, A Nath… - Nature Reviews …, 2023 - nature.com
Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis

O Hardiman, A Al-Chalabi, A Chio, EM Corr… - Nature reviews Disease …, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

[HTML][HTML] Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee

S Vucic, KHS Chen, MC Kiernan, M Hallett… - Clinical …, 2023 - Elsevier
The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di
Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial …

Amyotrophic lateral sclerosis: moving towards a new classification system

A Al-Chalabi, O Hardiman, MC Kiernan, A Chiò… - The Lancet …, 2016 - thelancet.com
Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that
primarily affects upper and lower motor neurons, but also frontotemporal and other regions …

The amyotrophic lateral sclerosis exposome: recent advances and future directions

SA Goutman, MG Savelieff, DG Jang, J Hur… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

A Al-Chalabi, LH Van Den Berg, J Veldink - Nature Reviews Neurology, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting
upper and lower motor neurons. The disease leads to relentlessly progressive weakness of …