Testicular cancer (TC) is the most common solid tumor among men aged between 15 and
40 years. TCs are highly aneuploid and the 12p isochromosome is the most frequent …

Testicular tumors are the most common tumors in adolescent and young men and germ cell
tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs …

Spermiation is the process by which mature spermatids are released from Sertoli cells into
the seminiferous tubule lumen prior to their passage to the epididymis. It takes place over …

Featuring over 600 full-color illustrations, the Third Edition of this definitive reference
provides comprehensive, current, and authoritative coverage of the entire spectrum of …

Platinum-based chemotherapies such as cisplatin are used as first-line treatment for many
cancers. Although there is often a high initial responsiveness, the majority of patients …

The Akt pathway, an important regulator of cell proliferation and survival, is deregulated in
many cancers. The pathway has achieved considerable importance due to the development …

Testicular cancer is a curable cancer. The success of physicians in curing the disease is
underpinned by multidisciplinary advances. Cisplatin-based combination chemotherapy and …

New data have challenged the convention that the adult Sertoli cell population is fixed and
unmodifiable. The Sertoli cell has two distinct functions: 1) formation of the seminiferous …

Recent years have led to a better understanding of the mechanisms underlying cisplatin
response and resistance in germ cell tumours (GCT), and several promising targets have …

Testicular germ cell tumors (TGCTs) are a cancer pharmacology success story with a
majority of patients cured even in the highly advanced and metastatic setting. Successful …