Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular
Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and …

The discovery of infectious proteins, denoted prions, was unexpected. After much debate
over the chemical basis of heredity, resolution of this issue began with the discovery that …

Due to their nanometric size, dendrimers have been considered as potentially suitable as
new vehicles for drug delivery since their infancy. The association of a dendrimer and a drug …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Nanotechnology, science, and engineering spearhead the 21st century revolution that is
leading to fundamental breakthroughs in the way materials, devices, and systems are …

High molecular weight polymers (> 20 000 Da) have been widely used as soluble drug
carriers to improve drug targeting and therapeutic efficacy. Dendritic polymers are …

Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru
decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions …

Exposure of susceptible neuroblastoma N2a cells to mouse scrapie prions leads to infection,
as evidenced by the continued presence of the scrapie form of the prion protein (PrPSc) and …

The design and preparation of new polyester dendrimer, poly (ethylene oxide) hybrid
systems for drug delivery and related therapeutic applications, are described. These …