Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) in
eukaryotic cells. Mitochondrial ROS production associated with a dysfunction of respiratory …

Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …

Apart from complex I (NADH: ubiquinone oxidoreductase) the mitochondrial cytochrome bc
1 complex (complex III; ubiquinol: cytochrome c oxidoreductase) has been identified as the …

The cyclopentenone unit is a very powerful synthon for the synthesis of a variety of bioactive
target molecules. This is due to the broad diversity of chemical modifications available for …

Angiogenesis is the process of blood vessel growth. The angiogenic switch consists of new
blood vessel formation that, in carcinogenesis, can lead to the transition from a harmless …

Neuroinflammation, for which microglia are the predominant contributors, is a significant risk
factor for cognitive dysfunction. Riboflavin (also known as vitamin B2) ameliorates cognitive …

Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen
species, which are both cellular signals and damaging oxidants. Superoxide production by …

Mitochondria are responsible for the majority of oxygen consumption in cells, and thus
represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years …