New insights into decap** enzymes and selective mRNA decay
E Grudzien‐Nogalska… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Removal of the 5′ end cap is a critical determinant controlling mRNA stability and efficient
gene expression. Removal of the cap is exquisitely controlled by multiple direct and indirect …
gene expression. Removal of the cap is exquisitely controlled by multiple direct and indirect …
Regulation of mRNA decap**
Decap** is a critical step in the control of mRNA stability and the regulation of gene
expression. Two major decap** enzymes involved in mRNA turnover have been …
expression. Two major decap** enzymes involved in mRNA turnover have been …
Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs
S Sharma, E Grudzien-Nogalska… - Nucleic acids …, 2020 - academic.oup.com
We recently reported the presence of nicotinamide adenine dinucleotide (NAD)-capped
RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decap** …
RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decap** …
Multiple mRNA decap** enzymes in mammalian cells
Regulation of RNA degradation plays an important role in the control of gene expression.
One mechanism of eukaryotic mRNA decay proceeds through an initial deadenylation …
One mechanism of eukaryotic mRNA decay proceeds through an initial deadenylation …
Structural and functional control of the eukaryotic mRNA decap** machinery
M Arribas-Layton, D Wu, J Lykke-Andersen… - Biochimica et Biophysica …, 2013 - Elsevier
The regulation of mRNA degradation is critical for proper gene expression. Many major
pathways for mRNA decay involve the removal of the 5′ 7-methyl guanosine (m7G) cap in …
pathways for mRNA decay involve the removal of the 5′ 7-methyl guanosine (m7G) cap in …
<? sty\usepackage {wasysym}?> Aptamer-based assay for high-throughput substrate profiling of RNA decap** enzymes
Recent years have led to the identification of a number of enzymes responsible for RNA
decap**. This has provided a basis for further research to identify their role, dependency …
decap**. This has provided a basis for further research to identify their role, dependency …
Structural and mechanistic basis of mammalian Nudt12 RNA deNADding
E Grudzien-Nogalska, Y Wu, X Jiao, H Cui… - Nature chemical …, 2019 - nature.com
We recently demonstrated that mammalian cells harbor nicotinamide adenine dinucleotide
(NAD)-capped messenger RNAs that are hydrolyzed by the DXO deNADding enzyme. Here …
(NAD)-capped messenger RNAs that are hydrolyzed by the DXO deNADding enzyme. Here …
Evidence that XRN4, an Arabidopsis homolog of exoribonuclease XRN1, preferentially impacts transcripts with certain sequences or in particular functional categories
LA Rymarquis, FF Souret, PJ Green - Rna, 2011 - rnajournal.cshlp.org
One of the major players controlling RNA decay is the cytoplasmic 5′-to-3′
exoribonuclease, which is conserved among eukaryotic organisms. In Arabidopsis, the 5 …
exoribonuclease, which is conserved among eukaryotic organisms. In Arabidopsis, the 5 …
Differential utilization of decap** enzymes in mammalian mRNA decay pathways
mRNA decap** is a crucial step in the regulation of mRNA stability and gene expression.
Dcp2 is an mRNA decap** enzyme that has been widely studied. We recently reported …
Dcp2 is an mRNA decap** enzyme that has been widely studied. We recently reported …
The complex enzymology of mRNA decap**: Enzymes of four classes cleave pyrophosphate bonds
S Kramer, AG McLennan - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
The 5′ ends of most RNAs are chemically modified to enable protection from nucleases. In
bacteria, this is often achieved by kee** the triphosphate terminus originating from …
bacteria, this is often achieved by kee** the triphosphate terminus originating from …