Virulence of the zoonotic agent of leptospirosis: still terra incognita?

M Picardeau - Nature Reviews Microbiology, 2017‏ - nature.com
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging
zoonotic disease that affects animals and humans worldwide. The success of leptospires as …

Current treatment options for leptospirosis: a mini-review

P Petakh, P Behzadi, V Oksenych… - Frontiers in …, 2024‏ - frontiersin.org
Leptospirosis, one of the most common global zoonotic infections, significantly impacts
global human health, infecting more than a million people and causing approximately …

Leptospira and leptospirosis

B Adler, A de la Peña Moctezuma - Veterinary microbiology, 2010‏ - Elsevier
Leptospirosis is the most wide spread zoonosis worldwide; it is present in all continents
except Antarctica and evidence for the carriage of Leptospira has been found in virtually all …

Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen

AI Ko, C Goarant, M Picardeau - Nature Reviews Microbiology, 2009‏ - nature.com
Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity
and mortality among impoverished populations. One hundred years after the discovery of …

Leptospira as an Emerging Pathogen: A Review of its Biology, Pathogenesis and Host Immune Responses

KV Evangelista, J Coburn - Future microbiology, 2010‏ - Taylor & Francis
Leptospirosis, the most widespread zoonosis in the world, is an emerging public health
problem, particularly in large urban centers of develo** countries. Several pathogenic …

Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host

B Singh, C Fleury, F Jalalvand… - FEMS microbiology …, 2012‏ - academic.oup.com
Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins

B Henderson, S Nair, J Pallas… - FEMS microbiology …, 2011‏ - academic.oup.com
Fibronectin, a large and essential multidomain glycoprotein, with multiple adhesive
properties, functioning as a key link between cells and their extracellular matrices, is now …

Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis

M Picardeau, DM Bulach, C Bouchier, RL Zuerner… - PloS one, 2008‏ - journals.plos.org
Leptospira biflexa is a free-living saprophytic spirochete present in aquatic environments.
We determined the genome sequence of L. biflexa, making it the first saprophytic Leptospira …

Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor

LMS Lery, L Frangeul, A Tomas, V Passet, AS Almeida… - BMC biology, 2014‏ - Springer
Background Klebsiella pneumoniae strains are pathogenic to animals and humans, in which
they are both a frequent cause of nosocomial infections and a re-emerging cause of severe …

Leptospira interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin, Laminin and Regulators of Complement

B Stevenson, HA Choy, M Pinne, ML Rotondi… - PloS one, 2007‏ - journals.plos.org
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the
bloodstream, then invades and colonizes a variety of host tissues. Infectious leptospires are …