Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin
In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the
underlying mechanism remains nebulous. In this work, we used cryo–electron tomography …
underlying mechanism remains nebulous. In this work, we used cryo–electron tomography …
A new generation of crystallographic validation tools for the protein data bank
This report presents the conclusions of the X-ray Validation Task Force of the worldwide
Protein Data Bank (PDB). The PDB has expanded massively since current criteria for …
Protein Data Bank (PDB). The PDB has expanded massively since current criteria for …
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-related
CoVs encode 3 tandem macrodomains within nonstructural protein 3 (nsp3). The first …
CoVs encode 3 tandem macrodomains within nonstructural protein 3 (nsp3). The first …
Bump-and-hole engineering identifies specific substrates of glycosyltransferases in living cells
Studying posttranslational modifications classically relies on experimental strategies that
oversimplify the complex biosynthetic machineries of living cells. Protein glycosylation …
oversimplify the complex biosynthetic machineries of living cells. Protein glycosylation …
Structure and function of the PiuA and PirA siderophore-drug receptors from Pseudomonas aeruginosa and Acinetobacter baumannii
L Moynié, A Luscher, D Rolo, D Pletzer… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The outer membrane of Gram-negative bacteria presents an efficient barrier to the
permeation of antimicrobial molecules. One strategy pursued to circumvent this obstacle is …
permeation of antimicrobial molecules. One strategy pursued to circumvent this obstacle is …
Active-site conformational fluctuations promote the enzymatic activity of NDM-1
ABSTRACT β-Lactam antibiotics are the mainstay for the treatment of bacterial infections.
However, elevated resistance to these antibiotics mediated by metallo-β-lactamases (MBLs) …
However, elevated resistance to these antibiotics mediated by metallo-β-lactamases (MBLs) …
Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8
D Farhat, F Rezaei, M Ristovski, Y Yang… - Journal of molecular …, 2022 - Elsevier
The ATP-binding cassette (ABC) sterol transporters are responsible for maintaining
cholesterol homeostasis in mammals by participating in reverse cholesterol transport (RCT) …
cholesterol homeostasis in mammals by participating in reverse cholesterol transport (RCT) …
Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical …
K Calvopiña, P Hinchliffe, J Brem… - Molecular …, 2017 - Wiley Online Library
Clavulanic acid and avibactam are clinically deployed serine β‐lactamase inhibitors,
important as a defence against antibacterial resistance. Bicyclic boronates are recently …
important as a defence against antibacterial resistance. Bicyclic boronates are recently …
Alternative Recognition of the Conserved Stem Epitope in Influenza A Virus Hemagglutinin by a VH3-30-Encoded Heterosubtypic Antibody
A Wyrzucki, C Dreyfus, I Kohler, M Steck… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT A human monoclonal heterosubtypic antibody, MAb 3.1, with its heavy chain
encoded by VH3-30, was isolated using phage display with immobilized hemagglutinin (HA) …
encoded by VH3-30, was isolated using phage display with immobilized hemagglutinin (HA) …
Structural and molecular dynamics studies of a C1‐oxidizing lytic polysaccharide monooxygenase from Heterobasidion irregulare reveal amino acids important for …
Lytic polysaccharide monooxygenases (LPMO s) are a group of recently discovered
enzymes that play important roles in the decomposition of recalcitrant polysaccharides …
enzymes that play important roles in the decomposition of recalcitrant polysaccharides …