Remediation of sites contaminated with toxic metals is particularly challenging. Unlike
organic compounds, metals cannot be degraded, and the cleanup usually requires their …

Transition metals such as copper are essential for many physiological processes yet can be
toxic at elevated levels. Other metals (eg lead) are nonessential and potentially highly toxic …

Abstract MEME (Multiple EM for Motif Elicitation) is one of the most widely used tools for
searching for novel 'signals' in sets of biological sequences. Applications include the …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as …

Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

Zinc is an essential nutrient for all organisms because this metal serves as a catalytic or
structural cofactor for many different proteins. Zinc-dependent proteins are found in the …

Starvation for amino acids induces Gcn4p, a transcriptional activator of amino acid
biosynthetic genes in Saccharomyces cerevisiae. In an effort to identify all genes regulated …

We explored transcriptional responses of the fission yeast Schizosaccharomyces pombe to
various environmental stresses. DNA microarrays were used to characterize changes in …

Zinc (Zn) is an essential micronutrient for plants and animals owing to its structural and
catalytic roles in many proteins. Zn deficiency affects around 2 billion people, mainly those …

The genetic code is degenerate. Each amino acid is encoded by up to six synonymous
codons; the choice between these codons influences gene expression. Here, we show that …