Regulation of placental development and its impact on fetal growth—new insights from mouse models
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …
As such, adequate placental function is instrumental for developmental progression …
Epigenetics and the placenta
ECM Nelissen, APA van Montfoort… - Human reproduction …, 2011 - academic.oup.com
BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
Although the role of ferroptosis in killing tumor cells is well established, recent studies
indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils …
indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils …
Unbalanced placental expression of imprinted genes in human intrauterine growth restriction
J McMinn, M Wei, N Schupf, J Cusmai, EB Johnson… - Placenta, 2006 - Elsevier
Imprinted genes control fetal and placental growth in mice and in rare human syndromes,
but the role of these genes in sporadic intrauterine growth restriction (IUGR) is less well …
but the role of these genes in sporadic intrauterine growth restriction (IUGR) is less well …
Convergent evolution of genomic imprinting in plants and mammals
Parental genomic imprinting is characterized by the expression of a selected panel of genes
from one of the two parental alleles. Recent evidence shows that DNA methylation and …
from one of the two parental alleles. Recent evidence shows that DNA methylation and …
The role and interaction of imprinted genes in human fetal growth
Identifying the genetic input for fetal growth will help to understand common, serious
complications of pregnancy such as fetal growth restriction. Genomic imprinting is an …
complications of pregnancy such as fetal growth restriction. Genomic imprinting is an …
Regulation of growth and metabolism by imprinted genes
FM Smith, AS Garfield, A Ward - Cytogenetic and genome research, 2006 - karger.com
A small sub-set of mammalian genes are subject to regulation by genomic imprinting such
that only one parental allele is active in at least some sites of expression. Imprinted genes …
that only one parental allele is active in at least some sites of expression. Imprinted genes …
Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells
The primary differentiation event during mammalian development occurs at the blastocyst
stage and leads to the delineation of the inner cell mass (ICM) and the trophectoderm (TE) …
stage and leads to the delineation of the inner cell mass (ICM) and the trophectoderm (TE) …
Seahorse brood pouch transcriptome reveals common genes associated with vertebrate pregnancy
Viviparity (live birth) has evolved more than 150 times in vertebrates, and represents an
excellent model system for studying the evolution of complex traits. There are at least 23 …
excellent model system for studying the evolution of complex traits. There are at least 23 …
Maternal PUFAs, placental epigenetics, and their relevance to fetal growth and brain development
Dietary polyunsaturated fatty acids (PUFAs), especially omega-3 (n-3) and n-6 long-chain
(LC) PUFAs, are indispensable for the fetus' brain supplied by the placenta. Despite being …
(LC) PUFAs, are indispensable for the fetus' brain supplied by the placenta. Despite being …