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Single molecule real-time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics
S Ardui, A Ameur, JR Vermeesch… - Nucleic acids …, 2018 - academic.oup.com
Short read massive parallel sequencing has emerged as a standard diagnostic tool in the
medical setting. However, short read technologies have inherent limitations such as GC …
medical setting. However, short read technologies have inherent limitations such as GC …
Metagenomic sequencing for microbial DNA in human samples: emerging technological advances
Whole genome metagenomic sequencing is a powerful platform enabling the simultaneous
identification of all genes from entirely different kingdoms of organisms in a complex sample …
identification of all genes from entirely different kingdoms of organisms in a complex sample …
Discovering multiple types of DNA methylation from bacteria and microbiome using nanopore sequencing
A Tourancheau, EA Mead, XS Zhang, G Fang - Nature methods, 2021 - nature.com
Bacterial DNA methylation occurs at diverse sequence contexts and plays important
functional roles in cellular defense and gene regulation. Existing methods for detecting DNA …
functional roles in cellular defense and gene regulation. Existing methods for detecting DNA …
Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution
The discovery of N6-methyldeoxyadenine (6mA) across eukaryotes led to a search for
additional epigenetic mechanisms. However, some studies have highlighted confounding …
additional epigenetic mechanisms. However, some studies have highlighted confounding …
Sequencing-based analysis of microbiomes
Microbiomes occupy a range of niches and, in addition to having diverse compositions, they
have varied functional roles that have an impact on agriculture, environmental sciences, and …
have varied functional roles that have an impact on agriculture, environmental sciences, and …
DISARM is a widespread bacterial defence system with broad anti-phage activities
The evolutionary pressure imposed by phage predation on bacteria and archaea has
resulted in the development of effective anti-phage defence mechanisms, including …
resulted in the development of effective anti-phage defence mechanisms, including …
The bacterial epigenome
MA Sánchez-Romero, J Casadesús - Nature Reviews Microbiology, 2020 - nature.com
In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …
Navigating the pitfalls of map** DNA and RNA modifications
Y Kong, EA Mead, G Fang - Nature Reviews Genetics, 2023 - nature.com
Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution map** of these modifications is …
important regulatory information. Reliable high-resolution map** of these modifications is …
Widespread adenine N6-methylation of active genes in fungi
Abstract N6-methyldeoxyadenine (6mA) is a noncanonical DNA base modification present
at low levels in plant and animal genomes,,,, but its prevalence and association with …
at low levels in plant and animal genomes,,,, but its prevalence and association with …
Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures
I Sobhani, E Bergsten, S Couffin, A Amiot… - Proceedings of the …, 2019 - pnas.org
Sporadic colorectal cancer (CRC) is a result of complex interactions between the host and
its environment. Environmental stressors act by causing host cell DNA alterations implicated …
its environment. Environmental stressors act by causing host cell DNA alterations implicated …