Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …

Mutations in mitochondrial DNA (mtDNA) play critical roles in many human diseases. In vivo
visualization of cells bearing mtDNA mutations is important for resolving the complexity of …

The fate of new mitochondrial and plastid mutations depends on their ability to persist and
spread among the numerous organellar genome copies within a cell (heteroplasmy). The …

Mitochondrial diseases, caused mainly by pathogenic mitochondrial DNA (mtDNA)
mutations, pose major challenges due to the lack of effective treatments. Investigating the …

The benefits of regular physical activity are related to delaying and reversing the onset of
ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases …

Human mitochondrial DNA (mtDNA) harbors essential mutations linked to aging,
neurodegenerative diseases, and complex muscle disorders. Due to its uniparental and …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

Phylogeny-based estimates suggesting a low germline mutation rate (μ) in baleen whales
have influenced research ranging from assessments of whaling impacts to evolutionary …

Oocytes play a crucial role in transmitting maternal mitochondrial DNA (mtDNA), essential
for the continuation of species. However, the effects of mitochondrial reactive oxygen …