Fezolinetant in the treatment of vasomotor symptoms associated with menopause

H Depypere, C Lademacher, E Siddiqui… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Although international clinical practice guidelines recognize a continued role
for menopausal hormone therapy (HT), particularly for symptomatic women< 60 years of age …

Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study

S Lederman, FD Ottery, A Cano, N Santoro, M Shapiro… - The Lancet, 2023 - thelancet.com
Background Neurokinin 3 receptor antagonists are potential non-hormonal therapies for the
treatment of vasomotor symptoms in menopausal women as options are scarce for those …

The role of gonadotropin‐releasing hormone neurons in polycystic ovary syndrome

CR McCartney, RE Campbell… - Journal of …, 2022 - Wiley Online Library
Given the critical central role of gonadotropin‐releasing hormone (GnRH) neurons in fertility,
it is not surprising that the GnRH neural network is implicated in the pathology of polycystic …

The British Menopause Society & Women's Health Concern 2020 recommendations on hormone replacement therapy in menopausal women

H Hamoda, N Panay, H Pedder, R Arya… - Post reproductive …, 2020 - journals.sagepub.com
The British Menopause Society & Women’s Health Concern 2020 recommendations on
hormone replacement therapy in menopausal women - Haitham Hamoda, Nick Panay …

Randomized controlled trial of neurokinin 3 receptor antagonist fezolinetant for treatment of polycystic ovary syndrome

GL Fraser, B Obermayer-Pietsch… - The Journal of …, 2021 - academic.oup.com
Context Polycystic ovary syndrome (PCOS), a highly prevalent endocrine disorder
characterized by hyperandrogenism, is the leading cause of anovulatory infertility. Objective …

[HTML][HTML] Neurokinin 1/3 receptor antagonists for menopausal women: A current systematic review and insights into the investigational non-hormonal therapy

F Hassan, A Saleem, SS Samuel, Z Sarfraz, A Sarfraz… - Medicine, 2023 - journals.lww.com
Background: Over 75% of menopausal women experience vasomotor symptoms (VMS),
such as night sweats and hot flashes. Despite the prevalence of these symptoms, there is …

Fezolinetant for the treatment of vasomotor symptoms associated with menopause: a meta-analysis

MP Chavez, E Pasqualotto, ROM Ferreira, A Hohl… - …, 2024 - Taylor & Francis
This systematic review and meta-analysis investigated the efficacy and safety of fezolinetant
for the treatment of moderate-to-severe vasomotor symptoms (VMS) associated with …

Efficacy and safety of fezolinetant for the treatment of menopause-associated vasomotor symptoms: a meta-analysis

KN Bonga, A Mishra, R Maiti, BM Padhy… - Obstetrics & …, 2022 - journals.lww.com
OBJECTIVE: To evaluate the efficacy and adverse events of fezolinetant for treating
vasomotor symptoms (VMS) of menopause. DATA SOURCES: PubMed/MEDLINE …

Fezolinetant's efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled …

AR Allam, MS Alhateem, AM Mahmoud - European Journal of Medical …, 2025 - Springer
Background Postmenopausal women are more likely to experience vasomotor symptoms
(VMS), such as heat sensation and sweating. Recent trials have investigated fezolinetant in …

A copper complex formed with neurokinin B: Binding stoichiometry, redox properties, self-assembly and cytotoxicity

Y Huang, N **a, M Chen, P Yang, L Liu, J Wang - Metallomics, 2020 - academic.oup.com
The tachykinin neuropeptide of neurokinin B (NKB) is a copper-binding amyloid peptide with
important roles in the regulation of physiological functions and pathophysiological …