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Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update
K Engle, G Kumar - European journal of medicinal chemistry, 2022 - Elsevier
Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …
Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …
and mechanistically distinct substrates against steep concentration gradients. Among the …
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
[HTML][HTML] The importance of the pyrazole scaffold in the design of protein kinases inhibitors as targeted anticancer therapies
The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
FGFR-TKI resistance in cancer: current status and perspectives
S Yue, Y Li, X Chen, J Wang, M Li, Y Chen… - Journal of hematology & …, 2021 - Springer
Fibroblast growth factor receptors (FGFRs) play key roles in promoting the proliferation,
differentiation, and migration of cancer cell. Inactivation of FGFRs by tyrosine kinase …
differentiation, and migration of cancer cell. Inactivation of FGFRs by tyrosine kinase …
FGF/FGFR-dependent molecular mechanisms underlying anti-cancer drug resistance
J Szymczyk, KD Sluzalska, I Materla, L Opalinski… - Cancers, 2021 - mdpi.com
Simple Summary Deregulation of the FGF/FGFR axis is associated with many types of
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2
CP Wu, SH Hsiao, YS Wu - Drug Resistance Updates, 2023 - Elsevier
The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in develo** multidrug resistance (MDR). Unfortunately …
a common mechanism involved in develo** multidrug resistance (MDR). Unfortunately …
Molecular modeling strategies of cancer multidrug resistance
G Yalcin-Ozkat - Drug Resistance Updates, 2021 - Elsevier
Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …
in cancer cases observed in the elderly population, as well as in children and adolescents …
Glutathione‐Sensitive Photosensitizer–Drug Conjugates Target the Mitochondria to Overcome Multi‐Drug Resistance in Cancer
W Song, H Yang, Y Wang, S Chen, W Zhong… - Advanced …, 2024 - Wiley Online Library
Multi‐drug resistance (MDR) is a major cause of cancer therapy failure. Photodynamic
therapy (PDT) is a promising modality that can circumvent MDR and synergize with …
therapy (PDT) is a promising modality that can circumvent MDR and synergize with …
Ribosomal protein L22‐like1 promotes prostate cancer progression by activating PI3K/Akt/mTOR signalling pathway
X Yi, C Zhang, B Liu, G Gao, Y Tang… - Journal of cellular …, 2023 - Wiley Online Library
Prostate cancer (PCa) is one of the most common malignancies in men. Ribosomal protein
L22‐like1 (RPL22L1), a component of the ribosomal 60 S subunit, is associated with cancer …
L22‐like1 (RPL22L1), a component of the ribosomal 60 S subunit, is associated with cancer …