Controlling mineral morphologies and structures in biological and synthetic systems
The unique and frequently beautiful morphologies that characterize many biominerals have
long been a source of fascination. While research began by looking first at individual …
long been a source of fascination. While research began by looking first at individual …
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …
been the primary model organisms used for the study of various biological phenomena …
Structure-based drug discovery of carbonic anhydrase inhibitors
CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2012 - Taylor & Francis
Inhibition of the metalloenzyme carbonic anhydrase (CA; EC 4.2. 1.1) has pharmacologic
applications in the field of anti-glaucoma, anti-convulsant and anti-cancer agents. But …
applications in the field of anti-glaucoma, anti-convulsant and anti-cancer agents. But …
Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein− ligand binding
VM Krishnamurthy, GK Kaufman, AR Urbach… - Chemical …, 2008 - ACS Publications
Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …
Carbonic anhydrase inhibitors
CT Supuran - Bioorganic & medicinal chemistry letters, 2010 - Elsevier
Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread enzymes in all organisms,
catalyzing CO2 hydration to bicarbonate and protons. Their inhibition is exploited clinically …
catalyzing CO2 hydration to bicarbonate and protons. Their inhibition is exploited clinically …
A new widespread subclass of carbonic anhydrase in marine phytoplankton
Most aquatic photoautotrophs depend on CO2-concentrating mechanisms (CCMs) to
maintain productivity at ambient concentrations of CO2, and carbonic anhydrase (CA) plays …
maintain productivity at ambient concentrations of CO2, and carbonic anhydrase (CA) plays …
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases
The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the
most lethal type of human malaria, contains a single gene annotated as encoding a carbonic …
most lethal type of human malaria, contains a single gene annotated as encoding a carbonic …
An overview of the bacterial carbonic anhydrases
Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking
Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
Carbonic anhydrase inhibitors and activators for novel therapeutic applications
CT Supuran - Future medicinal chemistry, 2011 - Taylor & Francis
Carbonic anhydrases (CAs, Enzyme Commission number 4.2. 1.1) catalyze a simple but
fundamental reaction, CO2 hydration to yield bicarbonate and protons. CAs belonging to the …
fundamental reaction, CO2 hydration to yield bicarbonate and protons. CAs belonging to the …