[HTML][HTML] Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond
Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …
of impaired tissues or organs. While current technologies can enhance the survival of …
Therapeutic potential of mesenchymal stem cells for diabetes
A Moreira, S Kahlenberg… - Journal of molecular …, 2017 - jme.bioscientifica.com
Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to
secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and …
secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and …
Engineering the vasculature for islet transplantation
The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …
Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury
Background Retinal and/or optic nerve injury is one of the leading causes of blindness due
to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress …
to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress …
Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
AM Billing, H Ben Hamidane, SS Dib, RJ Cotton… - Scientific reports, 2016 - nature.com
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected
by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from …
by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from …
Extracellular vesicles derived from human embryonic stem cell‐MSCs ameliorate cirrhosis in thioacetamide‐induced chronic liver injury
Various somatic tissue‐derived mesenchymal stromal cells (MSCs) have been considered
as an attractive therapeutic tool for treatment of liver diseases in which the secretion of …
as an attractive therapeutic tool for treatment of liver diseases in which the secretion of …
[HTML][HTML] Bioengineering the vascularized endocrine pancreas: a fine-tuned interplay between vascularization, extracellular-matrix-based scaffold architecture, and …
Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …
Production of mesenchymal stem cells through stem cell reprogramming
Mesenchymal stem cells (MSCs) possess a broad spectrum of therapeutic applications and
have been used in clinical trials. MSCs are mainly retrieved from adult or fetal tissues …
have been used in clinical trials. MSCs are mainly retrieved from adult or fetal tissues …
Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation
A major hindrance in islet transplantation as a feasible therapeutic approach for patients
with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in …
with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in …
Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach
The umbilical cord has been proved to be an easy-access, reliable, and useful source of
mesenchymal stem cells (MSC) for clinical applications due to its primitive …
mesenchymal stem cells (MSC) for clinical applications due to its primitive …