The heat shock response (HSR) is characterized by the induction of molecular chaperones
following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of …

Abstract Heat shock factor 1 (Hsf1) is an ancient transcription factor that monitors protein
homeostasis (proteostasis) and counteracts disturbances by triggering a transcriptional …

Ribosome biogenesis is a complex and energy-demanding process requiring tight
coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Given the …

Background Transcriptional regulation is a key aspect of environmental stress responses.
Heat stress induces transcriptional memory, ie, sustained induction or enhanced re …

Cells must sense and respond to sudden maladaptive environmental changes—stresses—
to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved …

To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-
proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute. Although …

Mammalian developmental and disease-associated genes concentrate large quantities of
the transcriptional machinery by forming membrane-less compartments known as …

Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the
heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones …

Efficient gene expression requires RNA polymerase II (RNAPII) to find chromatin targets
precisely in space and time. How RNAPII manages this complex diffusive search in three …

Heat shock induces a conserved transcriptional program regulated by heat shock factor 1
(Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced …