Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …

Mass spectrometry (MS) has become a powerful and widely utilized tool in the investigation
of protein thiol chemistry, biochemistry, and biology. Very early biochemical studies of …

The biological mechanisms underlying the development of myopia have not yet been
completely elucidated. The retina is critical for visual signal processing, which primarily …

Abstract Sirtuin 5 (SIRT5), localized in the mitochondria, has been identified as a protein
desuccinylase and demalonylase in the mitochondria since the depletion of SIRT5 boosted …

The “inverse drug discovery” strategy is a potent means of exploring the cellular targets of
latent electrophiles not typically used in medicinal chemistry. Cyclopropenone, a powerful …

Hydrogen‐deuterium exchange mass spectrometry (HDX‐MS) approach has become a
valuable analytical complement to traditional methods. HDX‐MS allows the identification of …

This study describes a sensitive bio-electrochemical detection method for extensively used
toxic organothiophosphate pesticides temephos and dimethoate, and organocarbamate …

Since its identification, HIV has continued to have a detrimental impact on the lives of
millions of people throughout the world. The protease of HIV is a major target in antiviral …

Background Hydrogen/deuterium exchange (HDX) coupled to mass spectrometry permits
analysis of structure, dynamics, and molecular interactions of proteins. HDX mass …

Recent studies suggest cysteine S-nitrosation of S-nitrosoglutathione reductase (GSNOR)
could regulate protein redox homeostasis.“Switch” assays enable discovery of putatively S …