The genetics and mechanisms of T cell acute lymphoblastic leukaemia
L Belver, A Ferrando - Nature Reviews Cancer, 2016 - nature.com
T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …
The genetics and molecular biology of T-ALL
T Girardi, C Vicente, J Cools… - Blood, The Journal of …, 2017 - ashpublications.org
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy caused by the
accumulation of genomic lesions that affect the development of T cells. For many years, it …
accumulation of genomic lesions that affect the development of T cells. For many years, it …
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled
with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute …
with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute …
[HTML][HTML] Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1 …
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1 …
[HTML][HTML] The molecular basis of T cell acute lymphoblastic leukemia
P Van Vlierberghe, A Ferrando - The Journal of clinical …, 2012 - Am Soc Clin Investig
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of
hematopoietic progenitors primed toward T cell development, as result of a multistep …
hematopoietic progenitors primed toward T cell development, as result of a multistep …
EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenoty** of normal, reactive and malignant leukocytes
JJM Van Dongen, L Lhermitte, S Böttcher, J Almeida… - Leukemia, 2012 - nature.com
Most consensus leukemia & lymphoma antibody panels consist of lists of markers based on
expert opinions, but they have not been validated. Here we present the validated EuroFlow …
expert opinions, but they have not been validated. Here we present the validated EuroFlow …
Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine
SP Hunger, CG Mullighan - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …
leading cause of cancer death in the young. In the last decade, microarray and sequencing …
Treatment of acute lymphoblastic leukemia
CH Pui, WE Evans - New England Journal of Medicine, 2006 - Mass Medical Soc
Although the overall cure rate of acute lymphoblastic leukemia (ALL) in children is about 80
percent, affected adults fare less well. This review considers recent advances in the …
percent, affected adults fare less well. This review considers recent advances in the …
The impact of translocations and gene fusions on cancer causation
Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
Tyrosine kinases as targets for cancer therapy
DS Krause, RA Van Etten - New England Journal of Medicine, 2005 - Mass Medical Soc
Tyrosine kinases, enzymes that catalyze the transfer of phosphate from ATP to tyrosine
residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest …
residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest …