Role of copper on mitochondrial function and metabolism
Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
Mitochondrial heterogeneity and adaptations to cellular needs
Although it is well described that mitochondria are at the epicentre of the energy demands of
a cell, it is becoming important to consider how each cell tailors its mitochondrial …
a cell, it is becoming important to consider how each cell tailors its mitochondrial …
Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation
Pluripotent stem cells hold great promise in regenerative medicine and developmental
biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle …
biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle …
[HTML][HTML] Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming
Platelets are known to enhance the wound-healing activity of mesenchymal stem cells
(MSCs). However, the mechanism by which platelets improve the therapeutic potential of …
(MSCs). However, the mechanism by which platelets improve the therapeutic potential of …
The role of mitochondrial ROS in the aging brain
The brain is the most complex human organ, consuming more energy than any other tissue
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …
BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation
MA Lampert, AM Orogo, RH Najor, BC Hammerling… - Autophagy, 2019 - Taylor & Francis
Cell-based therapies represent a very promising strategy to repair and regenerate the
injured heart to prevent progression to heart failure. To date, these therapies have had …
injured heart to prevent progression to heart failure. To date, these therapies have had …
[HTML][HTML] Mitochondria and cancer chemoresistance
Mitochondria, known for more than a century as the energy powerhouse of a cell, represent
key intracellular signaling hub that are emerging as important determinants of several …
key intracellular signaling hub that are emerging as important determinants of several …
Single-cell profiles and clinically useful properties of human mesenchymal stem cells of adipose and bone marrow origin
Background: Mesenchymal stem cells (MSCs) can be isolated from various tissues and can
present themselves as a promising cell source for cell-based therapies. Although adipose …
present themselves as a promising cell source for cell-based therapies. Although adipose …
[HTML][HTML] Regulation of adult neurogenesis in mammalian brain
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome
The ability to quantify differentiation potential of single cells is a task of critical importance.
Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation …
Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation …