The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …

Antiretroviral drugs that inhibit viral replication were expected to reduce transmission of HIV
by lowering the concentration of HIV in the genital tract. In 11 of 13 observational studies …

Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …

Background An interim analysis of data from the HIV Prevention Trials Network (HPTN) 052
trial showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked …

Background Use of antiretroviral treatment for HIV-1 infection has decreased AIDS-related
morbidity and mortality and prevents sexual transmission of HIV-1. However, the best time to …

Importance New data and antiretroviral regimens expand treatment choices in resource-rich
settings and warrant an update of recommendations to treat adults infected with human …

Initiation of antiretroviral therapy during the earliest stages of HIV-1 infection may limit the
seeding of a long-lasting viral reservoir, but long-term effects of early antiretroviral treatment …

Initiating antiretroviral therapy (ART) as early as the day of HIV diagnosis is a strategy of
increasing global interest to control the HIV epidemic and optimize the health of people …

Objective To reconstruct the local HIV-1 transmission network from 1996 to 2011 and use
network data to evaluate and guide efforts to interrupt transmission. Design HIV-1 pol …

Haematological and immunological abnormalities abound in HIV infections. Reduced CD4+
T cells, changes in cytokine profiles, and impaired immunity are the key immunological …