[HTML][HTML] Oral delivery of protein and peptide drugs: From non-specific formulation approaches to intestinal cell targeting strategies

G Chen, W Kang, W Li, S Chen, Y Gao - Theranostics, 2022 - ncbi.nlm.nih.gov
The past few years has witnessed a booming market of protein and peptide drugs, owing to
their superior efficiency and biocompatibility. Parenteral route is the most commonly …

Microencapsulation technology for delivery of enzymes in ruminant feed

N Almassri, FJ Trujillo, NS Terefe - Frontiers in Veterinary Science, 2024 - frontiersin.org
The ruminant digestive system is uniquely designed to make efficient use of high-fibre feed,
including forages. Between 40 to 100% of the ruminant diet consists of forages which are …

Optimization of a novel in situ gel for sustained ocular drug delivery using Box-Behnken design: In vitro, ex vivo, in vivo and human studies

KM Ranch, FA Maulvi, MJ Naik, AR Koli… - International Journal of …, 2019 - Elsevier
The aim of the present research work was to formulate, optimize and evaluate the in-situ gel
for the ophthalmic drug delivery using the combination of gellan gum and carbopol 934P …

[HTML][HTML] Premium ethylcellulose polymer based architectures at work in drug delivery

OA Adeleke - International Journal of Pharmaceutics: X, 2019 - Elsevier
Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely
employed as biocompatible templates for the design of novel drug delivery systems. They …

Bioavailability enhancement of repaglinide from transdermally applied nanostructured lipid carrier gel: optimization, in vitro and in vivo studies

SS Pandey, MA Patel, DT Desai, HP Patel… - Journal of Drug Delivery …, 2020 - Elsevier
Repaglinide (RG) is an effective anti-diabetic drug (BCS class II) with limited oral
bioavailability< 55% due to poor solubility and high first-pass hepatic metabolism. The aim …

Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system …

HP Patel, AV Vasandia, R Jha, BV Desai… - Pharmaceutical …, 2024 - Taylor & Francis
Abstract Doxepin, a Class-I Biopharmaceutics Drug Disposition Classification System
(BDDCS) drug, exhibits poor bioavailability due to extensive first-pass metabolism. This …

Cyclosporine laden tailored microemulsion-gel depot for effective treatment of psoriasis: In vitro and in vivo studies

SS Pandey, FA Maulvi, PS Patel, MR Shukla… - Colloids and Surfaces B …, 2020 - Elsevier
Psoriasis is a widespread chronic disease affecting 1–3% of total population. In major cases
(> 80%), it is treated by topical application of corticosteroids. However, the topical route is …

Topical delivery of cyclosporine loaded tailored niosomal nanocarriers for improved skin penetration and deposition in psoriasis: Optimization, ex vivo and animal …

SS Pandey, KM Shah, FA Maulvi, DT Desai… - Journal of Drug Delivery …, 2021 - Elsevier
Psoriasis is a chronic disease treated using topical application of calcineurin inhibitors.
However, due to physico-chemical nature of psoriatic stratum corneum, the topical drug …

Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: Optimization and in vivo …

HP Patel, PS Chaudhari, PA Gandhi, BV Desai… - International Journal of …, 2021 - Elsevier
Clozapine is widely used to treat schizophrenia as an atypical antipsychotic. Low solubility,
poor dissolution rate, degradation in the gastrointestinal tract, high hepatic first-pass …

Tailored Doxycycline Hyclate Loaded In Situ Gel for the Treatment of Periodontitis: Optimization, In Vitro Characterization, and Antimicrobial Studies

KM Ranch, FA Maulvi, AR Koli, DT Desai, RK Parikh… - AAPS …, 2021 - Springer
Currently, periodontitis is treated by oral dosage forms (antibiotics) which shows systemic
side effects and failed to reach the therapeutic concentration (above minimum inhibitory …