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Advances in spheroids and organoids on a chip
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …
medicine and drug screening. They replicate the structural and functional characteristics of …
3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare
In the last few years, 3D printing has emerged as a promising alternative for the fabrication
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
Autonomous microlasers for profiling extracellular vesicles from cancer spheroids
Self-propelled micro/nanomotors are emergent intelligent sensors for analyzing extracellular
biomarkers in circulating biological fluids. Conventional luminescent motors are often …
biomarkers in circulating biological fluids. Conventional luminescent motors are often …
Advancements in 3D cell culture systems for personalizing anti-cancer therapies
Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …
Emerging tumor-on-chips with electrochemical biosensors
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …
attention and interest. Advances in tissue engineering and microfluidics have led to the …
Mammary tumor organoid culture in non‐adhesive alginate for luminal mechanics and high‐throughput drug screening
Mammary tumor organoids have become a promising in vitro model for drug screening and
personalized medicine. However, the dependency on the basement membrane extract …
personalized medicine. However, the dependency on the basement membrane extract …
Responsive sensors of upconversion nanoparticles
Upconversion nanoparticles are a class of luminescent materials that convert longer-
wavelength near-infrared photons into visible and ultraviolet emissions. They can respond to …
wavelength near-infrared photons into visible and ultraviolet emissions. They can respond to …
Flipped well-plate hanging-drop technique for growing three-dimensional tumors
Three-dimensional (3D) tumor culture techniques are gaining popularity as in vitro models of
tumoral tissue analogues. Despite the widespread interest, need, and present-day effort …
tumoral tissue analogues. Despite the widespread interest, need, and present-day effort …
A microfluidic multisize spheroid array for multiparametric screening of anticancer drugs and blood–brain barrier transport properties
Physiological‐relevant in vitro tissue models with their promise of better predictability have
the potential to improve drug screening outcomes in preclinical studies. Despite the …
the potential to improve drug screening outcomes in preclinical studies. Despite the …
Simple droplet microfluidics platform for drug screening on cancer spheroids
C Parent, KR Melayil, Y Zhou, V Aubert, D Surdez… - Lab on a Chip, 2023 - pubs.rsc.org
3D in vitro biological systems are progressively replacing 2D systems to increase the
physiological relevance of cellular studies. Microfluidics-based approaches can be powerful …
physiological relevance of cellular studies. Microfluidics-based approaches can be powerful …