Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

Materials design for bone-tissue engineering

GL Koons, M Diba, AG Mikos - Nature Reviews Materials, 2020 - nature.com
Successful materials design for bone-tissue engineering requires an understanding of the
composition and structure of native bone tissue, as well as appropriate selection of …

Mesoporous silica nanoparticles for drug delivery

M Manzano, M Vallet‐Regí - Advanced functional materials, 2020 - Wiley Online Library
In recent years, nanomedicine has emerged at the forefront of nanotechnology, generating
great expectations in the biomedical field. Researchers are develo** novel nanoparticles …

Nanodelivery of nucleic acids

BB Mendes, J Conniot, A Avital, D Yao… - Nature reviews …, 2022 - nature.com
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment

X Liu, F Li, Z Dong, C Gu, D Mao, J Chen, L Luo… - Science …, 2023 - science.org
Current clinical approaches to osteoporosis primarily target osteoclast biology, overlooking
the synergistic role of bone cells, immune cells, cytokines, and inorganic components in …

Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

S Zhou, Q Zhong, Y Wang, P Hu, W Zhong… - Coordination Chemistry …, 2022 - Elsevier
In recent years, the unprecedented advances of biomedical nanotechnology have spurred
the development of drug delivery systems (DDSs) based on multifarious nanomaterials in …

Recent trends in the development of bone regenerative biomaterials

G Tang, Z Liu, Y Liu, J Yu, X Wang, Z Tan… - Frontiers in Cell and …, 2021 - frontiersin.org
The goal of a biomaterial is to support the bone tissue regeneration process at the defect site
and eventually degrade in situ and get replaced with the newly generated bone tissue …

Biomedical applications of mesoporous silica nanoparticles as a drug delivery carrier

H Ahmed, SS Gomte, E Prathyusha… - Journal of Drug Delivery …, 2022 - Elsevier
Mesoporous silica nanoparticles (MSNs) attracted biomedical researchers due to their
unique properties like large surface area, pore-volume, and surface-active groups. These …

Advances in materials-based therapeutic strategies against osteoporosis

C Lei, J Song, S Li, Y Zhu, M Liu, M Wan, Z Mu, FR Tay… - Biomaterials, 2023 - Elsevier
Osteoporosis is caused by the disruption in homeostasis between bone formation and bone
resorption. Conventional management of osteoporosis involves systematic drug …

[HTML][HTML] Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis

H Liu, H Zhang, S Wang, J Cui, W Weng, X Liu… - Composites Part B …, 2023 - Elsevier
Osteoporosis (OP), characterized by decreased bone mass and destruction of bone
microarchitecture, is the most common bone degenerative disease. Conventional treatments …