The structure of the nervous system is extraordinarily complicated because individual
neurons are interconnected to hundreds or even thousands of other cells in networks that …

We describe automated technologies to probe the structure of neural tissue at nanometer
resolution and use them to generate a saturated reconstruction of a sub-volume of mouse …

Neural circuits can be reconstructed from brain images acquired by serial section electron
microscopy. Image analysis has been performed by manual labor for half a century, and …

Myelin is best known for its role in increasing the conduction velocity and metabolic
efficiency of long-range excitatory axons. Accordingly, the myelin observed in neocortical …

To facilitate fine-scale phenoty** of whole specimens, we describe here a set of tissue
fixation-embedding, detergent-clearing and staining protocols that can be used to transform …

A common feature in many neuroscience datasets is the presence of hierarchical data
structures, most commonly recording the activity of multiple neurons in multiple animals …

Understanding the mechanisms of neural computation and learning will require knowledge
of the underlying circuitry. Because it is difficult to directly measure the wiring diagrams of …

The sweetpotato whitefly Bemisia tabaci is a highly destructive agricultural and ornamental
crop pest. It damages host plants through both phloem feeding and vectoring plant …

Methods for resolving the three-dimensional (3D) microstructure of the brain typically start by
thinly slicing and staining the brain, followed by imaging numerous individual sections with …

To the Editor—Recent technological developments, such as high-throughput imaging and
sequencing, enable experimentalists to collect increasingly large, complex, and …