There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection
has many limitations, including being confounded by bacillus Calmette-Guérin (BCG) …

Summary On May 2, 2005, a new in vitro test, QuantiFERON®-TB Gold (QFT-G, Cellestis
Limited, Carnegie, Victoria, Australia), received final approval from the US Food and Drug …

The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …

There is no reliable means of detecting latent M. tuberculosis infection, and even in patients
with active tuberculosis, infection is often unconfirmed. We hypothesized that M. tuberculosis …

Rationale: T-cell responses during tuberculosis (TB) help contain Mycobacterium
tuberculosis in vivo but also cause collateral damage to host tissues. Immune regulatory …

Tuberculosis (TB) is an international public health priority and kills almost two million people
annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and …