Chronic pain causes Tau-mediated hippocampal pathology and memory deficits

SR Guerreiro, MR Guimaraes, JM Silva, C Dioli… - Molecular …, 2022 - nature.com
Persistent pain has been recently suggested as a risk factor for dementia. Indeed, chronic
pain is frequently accompanied by maladaptive brain plasticity and cognitive deficits whose …

[HTML][HTML] Tolperisone hydrochloride improves motor functions in Parkinson's disease via MMP-9 inhibition and by downregulating p38 MAPK and ERK1/2 signaling …

B Zaman, I Mostafa, T Hassan, S Ahmed… - Biomedicine & …, 2024 - Elsevier
The mitogen-activated protein kinase (MAPK) signaling pathway, particularly the p38 MAPK
and ERK1/2, has been implicated in the pathogenesis of Parkinson's disease (PD). Recent …

Urolithin a prevents sleep-deprivation-induced neuroinflammation and mitochondrial dysfunction in young and aged mice

A Misrani, S Tabassum, Z Zhang, S Tan, C Long - Molecular Neurobiology, 2024 - Springer
Sleep deprivation (SD) has reached epidemic proportions worldwide and negatively affects
people of all ages. Cognitive impairment induced by SD involves neuroinflammation and …

The mutated cytoplasmic fragile X messenger ribonucleoprotein 1 (FMR1)‐interacting protein 2 (CYFIP2 S968F) regulates cocaine‐induced reward behaviour and …

YJ Kim, K Kim, Y Lee, HW Min, YH Ko… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Cytoplasmic fragile X messenger ribonucleoprotein 1 (FMR1)‐
interacting protein 2 (CYFIP2), as a component of the Wiskott–Aldrich syndrome protein …

Mitochondrial deficits with neural and social damage in early-stage Alzheimer's disease model mice

A Misrani, S Tabassum, Q Huo, S Tabassum… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Mitochondrial dysfunction is thought to be an early event in the onset and progression of AD; …

[HTML][HTML] An optimized and detailed step-by-step protocol for the analysis of neuronal morphology in golgi-stained fetal sheep brain

I Dudink, TA White, M Ardalan, C Mallard… - Developmental …, 2022 - karger.com
Antenatal brain development during the final trimester of human pregnancy is a time when
mature neurons become increasingly complex in morphology, through axonal and dendritic …

Effects of topiramate on morphological and structural alterations of the anterior cingulate cortex in aggressive socially isolated mice

I Chaibi, I Ait-Mansour, M Tari, M Bennis… - …, 2023 - Springer
Rationale Topiramate, an approved antiepileptic drug, was found effective in treating
aggressive symptoms in humans and rodents. However, the effects and mechanisms of …

[HTML][HTML] A terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity

S Gao, L Zhang, X Wang, R Li, L Han, X **ong, Q Jiang… - Brain Research, 2023 - Elsevier
Stress is an important environmental factor affecting mental health that cannot be ignored.
Moreover, due to the great physiological differences between males and females, the effects …

Adolescent administration of ketamine impairs excitatory synapse formation onto parvalbumin-positive GABAergic interneurons in mouse prefrontal cortex

JW Zhang, HQ Zhou, Z Zhu, YY Ding, Y He… - Biochemical and …, 2024 - Elsevier
Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, induces deficits in
cognition and information processing following chronic abuse. Adolescent ketamine misuse …

银染高尔基染色法用于神经元完整结构成像.

周峰, 蔡小青, 汤乔伟, 诸颖… - Chinese Journal of …, 2024 - search.ebscohost.com
摘要高尔基染色是神经元树突和树突棘可视化的经典方法, 目前仍被广泛用于神经元形态可视化
. 银高尔基染色目前存在易产生黑色沉淀, 染色神经元形态结构不完整等问题 …