Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Stem cell markers, including NANOG, have been implicated in various cancers; however,
the functional contribution of NANOG to cancer pathogenesis has remained unclear. Here …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Germ cell development creates totipotency through genetic as well as epigenetic regulation
of the genome function. Primordial germ cells (PGCs) are the first germ cell population …

Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In
humans and other mammals, determinations of the expression and activity of alkaline …

A cohort of genes associated with embryonic stem (ES) cell behaviour, including NANOG,
are expressed in a number of human cancers. They form an ES‐like signature we first …

Complete maturation of oocytes is essential for the developmental competence of embryos.
Any interventions in the growth phase of the oocyte and the follicle in the ovary will affect …

Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in
unipotent primordial germ cells (PGCs) in mice, where its precise role is yet unclear,,. We …

Precise self-renewal of the germ cell lineage is fundamental to fertility and reproductive
success. The early precursors for the germ lineage, primordial germ cells (PGCs), survive …