SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

M Khan, SJ Yoo, M Clijsters, W Backaert, A Vanstapel… - Cell, 2021 - cell.com
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure …

Age-specific nasal epithelial responses to SARS-CoV-2 infection

MNJ Woodall, AM Cujba, KB Worlock, KM Case… - Nature …, 2024 - nature.com
Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk
of mortality in infected people over 85 years of age remains high. Here we investigate …

SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

CT Wu, PV Lidsky, Y **ao, R Cheng, IT Lee… - Cell, 2023 - cell.com
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …

SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity

JME Lim, AT Tan, N Le Bert, SK Hang… - Journal of Experimental …, 2022 - rupress.org
Rapid recognition of SARS-CoV-2–infected cells by resident T cells in the upper airway
might provide an important layer of protection against COVID-19. Whether parenteral SARS …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence

D Focosi, F Maggi, A Casadevall - Viruses, 2022 - mdpi.com
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …

COVID-19 and the vasculature: current aspects and long-term consequences

B Martinez-Salazar, M Holwerda, C Stüdle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …

Assessing the generation of tissue resident memory T cells by vaccines

E Rotrosen, TS Kupper - Nature Reviews Immunology, 2023 - nature.com
Vaccines have been a hugely successful public health intervention, virtually eliminating
many once common diseases of childhood. However, they have had less success in …