Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
The biology of innate lymphoid cells
D Artis, H Spits - Nature, 2015 - nature.com
The innate immune system is composed of a diverse array of evolutionarily ancient
haematopoietic cell types, including dendritic cells, monocytes, macrophages and …
haematopoietic cell types, including dendritic cells, monocytes, macrophages and …
The role of IL‐17 and related cytokines in inflammatory autoimmune diseases
T Kuwabara, F Ishikawa, M Kondo… - Mediators of …, 2017 - Wiley Online Library
Interleukin‐17 (IL‐17) induces the production of granulocyte colony‐stimulating factor (G‐
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …
Innate lymphoid cells: a new paradigm in immunology
BACKGROUND Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror
the phenotypes and functions of T cells. Natural killer (NK) cells can be considered the …
the phenotypes and functions of T cells. Natural killer (NK) cells can be considered the …
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …
revision of the TH subset paradigm and substantial progress has been made in deciphering …
[HTML][HTML] Interleukin-12 and-23 control plasticity of CD127+ group 1 and group 3 innate lymphoid cells in the intestinal lamina propria
Human group 1 ILCs consist of at least three phenotypically distinct subsets, including NK
cells, CD127+ ILC1, and intraepithelial CD103+ ILC1. In inflamed intestinal tissues from …
cells, CD127+ ILC1, and intraepithelial CD103+ ILC1. In inflamed intestinal tissues from …
The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
M Noack, P Miossec - Autoimmunity reviews, 2014 - Elsevier
This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …
IL-17 in chronic inflammation: from discovery to targeting
A Beringer, M Noack, P Miossec - Trends in molecular medicine, 2016 - cell.com
Interleukin-17 (IL-17) is a cytokine which elicits protection against extracellular bacterial and
fungal infections and which plays important roles in inflammation. However, when produced …
fungal infections and which plays important roles in inflammation. However, when produced …