The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Background Intravitreal aflibercept 8 mg could improve treatment outcomes and provide
sustained disease control in patients with neovascular age-related macular degeneration …

Non-small cell lung cancer (NSCLC) is the leading cause of death by cancer worldwide.
Despite developments in therapeutic approaches for the past few decades, the 5-year …

Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Diabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age
populations. Fat mass and obesity-associated protein (FTO) is an N6-methyladenosine …

Background Ocular neovascularization is a leading cause of blindness. Retinal microglia
have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the …

Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high
mortality rate. It is regarded as a significant public health issue because of its complicated …

Bone marrow mesenchymal stromal cell-derived exosomes (BMSC-Exos) can recruit stem
cells for bone repair, with neovessels serving as the main migratory channel for stem cells to …