Apolipoprotein AI (ApoA-I), the major protein component of high-density lipoproteins (HDL)
is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune …

Highlights•PDI is an important oxidase, reductase, isomerase and molecular
chaperone.•PDI expression is up-regulated in select types of cancers.•Silencing PDI results …

Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …

Prostate cancer is the most common malignancy and the second leading cause of cancer-
related deaths in men. One common treatment is androgen-deprivation therapy, which …

BACKGROUND The key to a more effective diagnosis, prognosis, and therapeutic
management of prostate cancer (PCa) could lie in the direct analysis of cancer tissue. In this …

The clinical and fundamental research in prostate cancer-the most common urological
cancer in men-is currently entering the proteomic and genomic era. The focus has switched …

In prostate cancer and other malignancies sensitive and robust biomarkers are lacking or
have relevant limitations. Prostate specific antigen (PSA), the only biomarker widely used in …

Despite the overall success of prostate specific antigen (PSA) in screening and detection of
prostate cancer (PCa), its use has been limited due to the lack of specificity. The principal …

Androgen deprivation constitutes the principal therapy for advanced and metastatic prostate
cancers. However, this therapeutic intervention usually results in the transition to a more …

PURPOSE: Prostate Cancer (PCa) represents the second most frequent type of tumor in
men worldwide. Incidence increases with patient age and represents the most important risk …