Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

[HTML][HTML] Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

D Ha, N Yang, V Nadithe - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Exosomes are small intracellular membrane-based vesicles with different compositions that
are involved in several biological and pathological processes. The exploitation of exosomes …

Phosphoinositides: tiny lipids with giant impact on cell regulation

T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Sorting mechanisms for MicroRNAs into extracellular vesicles and their associated diseases

M Groot, H Lee - Cells, 2020 - mdpi.com
Extracellular vesicles (EV) are secretory membranous elements used by cells to transport
proteins, lipids, mRNAs, and microRNAs (miRNAs). While their existence has been known …

Exosomes: endosomal-derived vesicles ship** extracellular messages

B Février, G Raposo - Current opinion in cell biology, 2004 - Elsevier
Exosomes are membrane vesicles released into the extracellular environment upon exocytic
fusion of multivesicular endosomes with the cell surface. They have a particular composition …

Body fluid derived exosomes as a novel template for clinical diagnostics

S Keller, J Ridinger, AK Rupp, JWG Janssen… - Journal of translational …, 2011 - Springer
Background Exosomes are small membrane vesicles with a size of 40-100 nm that are
released by different cell types from a late endosomal cellular compartment. They can be …

Biodistribution, clearance, and long‐term fate of clinically relevant nanomaterials

J Bourquin, A Milosevic, D Hauser, R Lehner… - Advanced …, 2018 - Wiley Online Library
Realization of the immense potential of nanomaterials for biomedical applications will
require a thorough understanding of how they interact with cells, tissues, and organs. There …

Exosomes are released by cultured cortical neurones

J Fauré, G Lachenal, M Court, J Hirrlinger… - Molecular and Cellular …, 2006 - Elsevier
Accumulating evidence shows that several cell types have the capacity to secrete
membrane proteins by incorporating them into exosomes, which are small lipid vesicles …

Biogenesis and function of multivesicular bodies

RC Piper, DJ Katzmann - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
The two major cellular sites for membrane protein degradation are the proteasome and the
lysosome. Ubiquitin attachment is a sorting signal for both degradation routes. For lysosomal …

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

T Pawson - Cell, 2004 - cell.com
Over the last two decades, a new and unifying concept of cellular organization has emerged
in which modular protein-protein interactions provide an underlying framework through …