In spite of significant progress towards malaria control and elimination achieved in South
America in the 2000s, this mosquito-transmitted tropical disease remains an important public …

Background: Rhesus (Rh) disease and extreme hyperbilirubinemia (EHB) result in neonatal
mortality and long-term neurodevelopmental impairment, yet there are no estimates of their …

At any age, disabling hearing impairment has a profound impact on interpersonal
communication, psychosocial well-being, quality of life and economic independence …

Background Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been
associated with relapse prevention through the clearance of P. vivax parasitemia and …

Abstract Background Treatment of Plasmodium vivax malaria requires the clearing of
asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared …

Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

Vivax malaria threatens patients despite relatively low-grade parasitemias in peripheral
blood. The tenet of death as a rare outcome, derived from antiquated and flawed clinical …

Race and ethnicity can contribute to interindividual differences in drug exposure and/or
response, which may alter risk–benefit in certain populations. Approximately one‐fifth of new …

Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose
phosphate pathway which produces nicotinamide adenine dinucleotide phosphate …

G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …