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[HTML][HTML] Recent advances in sensing the inter-biomolecular interactions at the nanoscale–A comprehensive review of AFM-based force spectroscopy
Biomolecular interactions underpin most processes inside the cell. Hence, a precise and
quantitative understanding of molecular association and dissociation events is crucial, not …
quantitative understanding of molecular association and dissociation events is crucial, not …
Glycosylated gold nanoparticles in point of care diagnostics: From aggregation to lateral flow
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …
The SARS-COV-2 spike protein binds sialic acids and enables rapid detection in a lateral flow point of care diagnostic device
There is an urgent need to understand the behavior of the novel coronavirus (SARS-COV-2),
which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a …
which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a …
Automation and data-driven design of polymer therapeutics
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …
structural parameters such as length, composition, architecture, and valency. To facilitate …
State-of-the-Art of Nanodiagnostics and Nanotherapeutics against SARS-CoV-2
The pandemic outbreak of SARS-CoV-2, with millions of infected patients worldwide, has
severely challenged all aspects of public health. In this regard, early and rapid detection of …
severely challenged all aspects of public health. In this regard, early and rapid detection of …
Plasmonic detection of SARS-CoV-2 spike protein with polymer-stabilized glycosylated gold nanorods
The COVID-19 pandemic has highlighted the need for innovative biosensing, diagnostic,
and surveillance platforms. Here we report that glycosylated, polymer-stabilized, gold …
and surveillance platforms. Here we report that glycosylated, polymer-stabilized, gold …
Engineering micro–nanomaterials for biomedical translation
Engineered nano–bio interfaces–driven by vertical micro/nanoneedles, nanoparticles, organ‐
on‐chip devices, and a diversity of nanosubstrates for mass spectroscopy imaging–are …
on‐chip devices, and a diversity of nanosubstrates for mass spectroscopy imaging–are …
Plasmonic properties of colloidal assemblies
The assembly of metal nanoparticles into supracolloidal structures unlocks optical features,
which can go beyond synergistic combinations of the properties of their primary building …
which can go beyond synergistic combinations of the properties of their primary building …
Toward glycomaterials with selectivity as well as affinity
Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity
toward carbohydrate binding proteins (eg, lectins) due to the nonlinear enhancement from …
toward carbohydrate binding proteins (eg, lectins) due to the nonlinear enhancement from …
Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands
Galectins are potential biomarkers and therapeutic targets. However, galectins display
broad affinity towards β-galactosides meaning glycan-based (nano) biosensors lack the …
broad affinity towards β-galactosides meaning glycan-based (nano) biosensors lack the …